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AZATIOPRINA.pgx

Test de ADN Farmacogenética AZATIOPRINApgx
Azatioprina.pgx DNA Test
The report includes an interpretation of the results so that it can be used immediately.   However, it is necessary to review in a Pharmacogenetic interpretation software g-Nomic, all the medication that the patient takes, as well as their nutrit...
The report includes an interpretation of the results so that it can be used immediately.   However, it is necessary to review in a Pharmacogenetic interpretation software g-Nomic, all the medication that the patient takes, as well as their nutritional life habits, to avoid a therapeutic failure.
Precio: 
299 €

Sample type:

Saliva

Delivery period:

20 - 30 days
Last update of the document Apr, 02/04/2024 - 12:21

Azatioprina.pgx  DNA Test

Azathioprine is an immunosuppressant that is used to treat autoimmune diseases, such as rheumatoid arthritis, and to prevent rejection in transplant patients (in this case associated with other medications).

Treatment is associated with dose-dependent adverse effects, such as neutropenia and hepatotoxicity. These serious adverse effects limit the usable dose, given that they are closely related to plasma levels.

The elimination of azathioprine depends on the activity of the TPMT enzyme. The gene that encodes this enzyme has genetic variability in the form of loss-of-function alleles. The TPMT deficit is a predictor of poor tolerability of azathioprine and even life-threatening adverse effects.

There is also evidence of polymorphisms in the NUDT15 gene, another gene related to the elimination of toxic metabolites, which affect safety and that could have special importance in Asian and Hispanic American populations, due to their greater frequency in these population groups.

Process translated by an automatic translator the original version is in Spanish

 

Sample collecting and processing procedure Saliva

You will receive the sample collection kit. You can request additional kits if you need it.

Sample collection kit content:
You will get a box with sample collection kit. Within the kit you will find:

  1. Saliva collector.
  2. Instructions for the sample collection.
  3. Required documents
  4. Security bag to enter the sample for shipment.
  5. Envelope bag.

Process to follow:

  1. Fill in the documents that we will send you, duly signed. You can also find these documents on this page, under the web tab: "Documents required".
  2. Follow the instructions for collecting the sample.
  3. After obtaining the sample, include it in the return envelope remember to put into the necessary documents.
  4. Call Eugenomic® on +34 93 292 29 63 or email info@eugenomic.com to request sample collection. No shipping costs on Spanish territory.
  5. An email confirmation will be sent when your sample si received.
  6. When the study will be completed you will receive a new e-mail to inform you that your report is already available in "My results"

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Profile Information

Azatioprina.pgx  DNA Test

Azathioprine is an immunosuppressant that is used to treat autoimmune diseases, such as rheumatoid arthritis, and to prevent rejection in transplant patients (in this case associated with other medications).

Treatment is associated with dose-dependent adverse effects, such as neutropenia and hepatotoxicity. These serious adverse effects limit the usable dose, given that they are closely related to plasma levels.

The elimination of azathioprine depends on the activity of the TPMT enzyme. The gene that encodes this enzyme has genetic variability in the form of loss-of-function alleles. The TPMT deficit is a predictor of poor tolerability of azathioprine and even life-threatening adverse effects.

There is also evidence of polymorphisms in the NUDT15 gene, another gene related to the elimination of toxic metabolites, which affect safety and that could have special importance in Asian and Hispanic American populations, due to their greater frequency in these population groups.

Process translated by an automatic translator the original version is in Spanish

 

Sample type and process to follow

Sample collecting and processing procedure Saliva

You will receive the sample collection kit. You can request additional kits if you need it.

Sample collection kit content:
You will get a box with sample collection kit. Within the kit you will find:

  1. Saliva collector.
  2. Instructions for the sample collection.
  3. Required documents
  4. Security bag to enter the sample for shipment.
  5. Envelope bag.

Process to follow:

  1. Fill in the documents that we will send you, duly signed. You can also find these documents on this page, under the web tab: "Documents required".
  2. Follow the instructions for collecting the sample.
  3. After obtaining the sample, include it in the return envelope remember to put into the necessary documents.
  4. Call Eugenomic® on +34 93 292 29 63 or email info@eugenomic.com to request sample collection. No shipping costs on Spanish territory.
  5. An email confirmation will be sent when your sample si received.
  6. When the study will be completed you will receive a new e-mail to inform you that your report is already available in "My results"

Documentación