The pharmacogenetics we can currently apply in clinical practice is based mainly on drug metabolism, including the cytochrome P450, or CYP. The CYPs include many enzymes involved in the metabolism of both different substances, exogenous such as drugs or environmental pollutants, or endogenous, such as hormones. In pharmacogenetics we are interested in the ones related to drug metabolism.
Most of these enzymes are genetically polymorphic, that is, they are not the same for all individuals, but thee are variants with normal activity, lower activity or non-functional. This determines the rate at which drugs are metabolized and eliminated.
Some active substances have no biological activity on its own, and must undergo metabolism to generate the active molecule. These drugs are known as prodrugs and changes in metabolic capacity may prevent the formation of the active compound.
GLOBALpgx analyzes the main CYP enzymes responsible for drug metabolism, covering the polymorphisms with frequencies higher than 1%, so it has an excellent coverage of genetic variability in drug metabolism.
The report includes an interpretation of the results for the most common prescription drugs that can be used immediately without other tools. However, if you have the appropriate software, such as applications available on www.eugenomic.com, the results can be applied to practically any drug.
Interpretation of the report in polytherapy
In this report, the "green" labeling of a certain drug with the patient's genes indicates that it can be prescribed in the standard dose conditions disclosed in the prospectus or those recommended by the physician. This applies in the case of monotherapy.
However, if the patient takes several medications, which is very common, although in the report would appear in "green" can cause adverse effects due to possible interactions between them, which can sometimes be severe, either by toxicity or by therapeutic failure.
Drugs are chemicals that may interfere the normal metabolism of other drugs. Interferences that are also applicable to the chemical substances of various medicinal plants and food supplements.
Consequently, the whole of the medication, together with the consumer products or life habits of the patient, must undergo an evaluation of pharmacological interactions.
Consulting g-Nomic® Pharmacogenetics interpretation software, before prescribing, is an effective aid to avoid most adverse effects or therapeutic failures due to medication.
g-Nomic® interrelates all drugs, herbs, nutritional supplements and lifestyle, with the patient's genes. It also advises the most appropriate dose to prescribe.
This text has been translated automatically using an electronic translator, so the Spanish version should prevail. Please check in case of doubt.