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THIOGUANINEpgx

TIOGUANINApgx
Adequate response to thioguanine treatment.
DNA test that studies genetic polymorphisms of TPMT gene to find out if thioguanine treatment will present toxicity. It has been observed that some individuals have non functional copies of the TPMT gene and therefore these patients have a low TPMT activity a...
DNA test that studies genetic polymorphisms of TPMT gene to find out if thioguanine treatment will present toxicity. It has been observed that some individuals have non functional copies of the TPMT gene and therefore these patients have a low TPMT activity and a reduced ability to remove the 6-mercaptopurine from their body. This has been associated with an increased sensitivity to the adverse effects of 6-mercaptopurine resultin in severe hematopoietic toxicity.
386,00

Sample type:

Saliva

Delivery period:

30 - 40 days from sample receipt.
Last update of the document Jun, 10/06/2019 - 13:49

Thioguanine DNA test

This drug is a chemotherapeutic agent used to treat hematological cancers, such as myeloid leukemia and acute lymphoblastic, although it can also be used for chronic lymphocytic leukemia. Because of its similarity to 6-mercaptopurine, cross-resistance phenomena occur.

The enzyme thiopurine methyltransferase (TPMT) metabolizes thioguanine, and its deficit implies a special sensitivity to adverse effects, highlighting myelosuppression. The effect is sometimes inevitable for the treatment to be effective, but patients who are deficient for TPMT can suffer serious episodes, since thioguanine has an affinity for bone marrow.

It has been observed that some people have non-functional copies of the TPMT gene and consequently these patients have a reduced TPMT activity and a lower capacity to eliminate thioguanine. This has been associated with a greater sensitivity to the adverse effects caused by thioguanine in the form of severe hematopoietic toxicity.

The identification of the deficiencies of TPMT due to genetic alterations allows to evaluate the prognosis in the treatment with thioguanine anticipating the appearance of hematopoietic toxicity. The TPMT genotype is a biomarker validated by the American FDA agency for toxicity due to thioguanine.

Unlike other similar drugs, such as 6-mercaptopurine, thioguanine does not require xanthine oxidase for its elimination and can be used without an increased risk of adverse effects, without it being necessary to adjust the dose, with drugs that inhibit this enzyme, which are contraindicated for 6-mercaptopurine.

Interpretation of the report in polytherapy

In this report, the "green" labeling of a certain drug with the patient's genes indicates that it can be prescribed in the standard dose conditions disclosed in the prospectus or those recommended by the physician. This applies in the case of monotherapy.

However, if the patient takes several medications, which is very common, although in the report would appear in "green" can cause adverse effects due to possible interactions between them, which can sometimes be severe, either by toxicity or by therapeutic failure.

Drugs are chemicals that may interfere the normal metabolism of other drugs. Interferences that are also applicable to the chemical substances of various medicinal plants and food supplements.

Consequently, the whole of the medication, together with the consumer products or life habits of the patient, must undergo an evaluation of pharmacological interactions.

Consulting g-Nomic® Pharmacogenetics interpretation software, before prescribing, is an effective aid to avoid most adverse effects or therapeutic failures due to medication.

g-Nomic® interrelates all drugs, herbs, nutritional supplements and lifestyle, with the patient's genes. It also advises the most appropriate dose to prescribe.

This text has been translated automatically using an electronic translator, so the Spanish version should prevail. Please check in case of doubt.

You will receive the sample collection kit. You can request additional kits if you need it.

Sample collection kit content:
You will get a box with sample collection kit. Within the kit you will find:

  1. Saliva collector.
  2. Instructions for the sample collection.
  3. Informed consent sheet and application form.
  4. Security bag to enter the sample for shipment.
  5. Envelope bag.

Process to follow:

  1. Follow the instructions for collecting the sample.
  2. After obtaining the sample, include it in the return envelope, remember to put into the informed consent sheet and the application form.
  3. No shipping costs on Spanish territory.
  4. An email confirmation will be sent when your sample si received.
  5. When the study will be completed you will receive a new e-mail to inform you that your report is already available in "My results".

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Profile Information

Thioguanine DNA test

This drug is a chemotherapeutic agent used to treat hematological cancers, such as myeloid leukemia and acute lymphoblastic, although it can also be used for chronic lymphocytic leukemia. Because of its similarity to 6-mercaptopurine, cross-resistance phenomena occur.

The enzyme thiopurine methyltransferase (TPMT) metabolizes thioguanine, and its deficit implies a special sensitivity to adverse effects, highlighting myelosuppression. The effect is sometimes inevitable for the treatment to be effective, but patients who are deficient for TPMT can suffer serious episodes, since thioguanine has an affinity for bone marrow.

It has been observed that some people have non-functional copies of the TPMT gene and consequently these patients have a reduced TPMT activity and a lower capacity to eliminate thioguanine. This has been associated with a greater sensitivity to the adverse effects caused by thioguanine in the form of severe hematopoietic toxicity.

The identification of the deficiencies of TPMT due to genetic alterations allows to evaluate the prognosis in the treatment with thioguanine anticipating the appearance of hematopoietic toxicity. The TPMT genotype is a biomarker validated by the American FDA agency for toxicity due to thioguanine.

Unlike other similar drugs, such as 6-mercaptopurine, thioguanine does not require xanthine oxidase for its elimination and can be used without an increased risk of adverse effects, without it being necessary to adjust the dose, with drugs that inhibit this enzyme, which are contraindicated for 6-mercaptopurine.

Interpretation of the report in polytherapy

In this report, the "green" labeling of a certain drug with the patient's genes indicates that it can be prescribed in the standard dose conditions disclosed in the prospectus or those recommended by the physician. This applies in the case of monotherapy.

However, if the patient takes several medications, which is very common, although in the report would appear in "green" can cause adverse effects due to possible interactions between them, which can sometimes be severe, either by toxicity or by therapeutic failure.

Drugs are chemicals that may interfere the normal metabolism of other drugs. Interferences that are also applicable to the chemical substances of various medicinal plants and food supplements.

Consequently, the whole of the medication, together with the consumer products or life habits of the patient, must undergo an evaluation of pharmacological interactions.

Consulting g-Nomic® Pharmacogenetics interpretation software, before prescribing, is an effective aid to avoid most adverse effects or therapeutic failures due to medication.

g-Nomic® interrelates all drugs, herbs, nutritional supplements and lifestyle, with the patient's genes. It also advises the most appropriate dose to prescribe.

This text has been translated automatically using an electronic translator, so the Spanish version should prevail. Please check in case of doubt.

Sample type and process to follow

You will receive the sample collection kit. You can request additional kits if you need it.

Sample collection kit content:
You will get a box with sample collection kit. Within the kit you will find:

  1. Saliva collector.
  2. Instructions for the sample collection.
  3. Informed consent sheet and application form.
  4. Security bag to enter the sample for shipment.
  5. Envelope bag.

Process to follow:

  1. Follow the instructions for collecting the sample.
  2. After obtaining the sample, include it in the return envelope, remember to put into the informed consent sheet and the application form.
  3. No shipping costs on Spanish territory.
  4. An email confirmation will be sent when your sample si received.
  5. When the study will be completed you will receive a new e-mail to inform you that your report is already available in "My results".

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