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METHOTREXATEpgx

Pharmacogenetics DNA test for methotrexate
Pharmacogenetics DNA test for methotrexate
Methotrexate is a drug used to treat some types of cancer, rheumatoid arthritis and psoriatic arthritis. It is very toxic, so the dose must be adjusted according to the patient polymorphisms and take into account interactions with other drugs.
139,00

Sample type:

Saliva

Delivery period:

30 - 40 days from sample receipt.
Last update of the document Jun, 10/06/2019 - 13:39

Methotrexate DNA Test

Methotrexate is a drug analogous to folic acid used in the treatment of cancer and in autoimmune diseases such as rheumatoid arthritis and psoriasis.

Methotrexate was first used in the mid-40s as an anti folate. It belongs to a class of drugs called antimetabolites. Depending on the dose, methotrexate treats cancer, slowing the growth of cancer cells.

Methotrexate is also used to treat psoriasis, slowing the growth of skin cells and disrupt desquamation. In turn for the treatment of rheumatoid arthritis by decreasing the activity of the immune system.

The action of methotrexate is based on having anti-proliferative and immunosuppressive activity, since it inhibits an enzyme that catalyzes a key step in the metabolism of folic acid, by regulating the amount of intracellular folate available for the synthesis of proteins and nucleic acids.

Methotrexate is also used to treat psoriasis, slowing its growth.

Methotrexate indirectly inhibits the enzyme MTHFR; therefore individualization of treatment with the drug based on the genetic polymorphisms of MTHFR (C677T and A1298C) is very important to avoid toxicity.

Methotrexate therapy reduces folic acid. People with decreased metabolism of folic acid, is recommended to take folic acid supplements to balance the cycle of folate, such important for biochemical functions of the body.

Interpretation of the report in polytherapy

In this report, the "green" labeling of a certain drug with the patient's genes indicates that it can be prescribed in the standard dose conditions disclosed in the prospectus or those recommended by the physician. This applies in the case of monotherapy.

However, if the patient takes several medications, which is very common, although in the report would appear in "green" can cause adverse effects due to possible interactions between them, which can sometimes be severe, either by toxicity or by therapeutic failure.

Drugs are chemicals that may interfere the normal metabolism of other drugs. Interferences that are also applicable to the chemical substances of various medicinal plants and food supplements.

Consequently, the whole of the medication, together with the consumer products or life habits of the patient, must undergo an evaluation of pharmacological interactions.

Consulting g-Nomic® Pharmacogenetics interpretation software, before prescribing, is an effective aid to avoid most adverse effects or therapeutic failures due to medication.

g-Nomic® interrelates all drugs, herbs, nutritional supplements and lifestyle, with the patient's genes. It also advises the most appropriate dose to prescribe.

This text has been translated automatically using an electronic translator, so the Spanish version should prevail. Please check in case of doubt.

 

You will receive the sample collection kit. You can request additional kits if you need it.

Sample collection kit content:
You will get a box with sample collection kit. Within the kit you will find:

  1. Saliva collector.
  2. Instructions for the sample collection.
  3. Informed consent sheet and application form.
  4. Security bag to enter the sample for shipment.
  5. Envelope bag.

Process to follow:

  1. Follow the instructions for collecting the sample.
  2. After obtaining the sample, include it in the return envelope, remember to put into the informed consent sheet and the application form.
  3. No shipping costs on Spanish territory.
  4. An email confirmation will be sent when your sample si received.
  5. When the study will be completed you will receive a new e-mail to inform you that your report is already available in "My results".

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Profile Information

Methotrexate DNA Test

Methotrexate is a drug analogous to folic acid used in the treatment of cancer and in autoimmune diseases such as rheumatoid arthritis and psoriasis.

Methotrexate was first used in the mid-40s as an anti folate. It belongs to a class of drugs called antimetabolites. Depending on the dose, methotrexate treats cancer, slowing the growth of cancer cells.

Methotrexate is also used to treat psoriasis, slowing the growth of skin cells and disrupt desquamation. In turn for the treatment of rheumatoid arthritis by decreasing the activity of the immune system.

The action of methotrexate is based on having anti-proliferative and immunosuppressive activity, since it inhibits an enzyme that catalyzes a key step in the metabolism of folic acid, by regulating the amount of intracellular folate available for the synthesis of proteins and nucleic acids.

Methotrexate is also used to treat psoriasis, slowing its growth.

Methotrexate indirectly inhibits the enzyme MTHFR; therefore individualization of treatment with the drug based on the genetic polymorphisms of MTHFR (C677T and A1298C) is very important to avoid toxicity.

Methotrexate therapy reduces folic acid. People with decreased metabolism of folic acid, is recommended to take folic acid supplements to balance the cycle of folate, such important for biochemical functions of the body.

Interpretation of the report in polytherapy

In this report, the "green" labeling of a certain drug with the patient's genes indicates that it can be prescribed in the standard dose conditions disclosed in the prospectus or those recommended by the physician. This applies in the case of monotherapy.

However, if the patient takes several medications, which is very common, although in the report would appear in "green" can cause adverse effects due to possible interactions between them, which can sometimes be severe, either by toxicity or by therapeutic failure.

Drugs are chemicals that may interfere the normal metabolism of other drugs. Interferences that are also applicable to the chemical substances of various medicinal plants and food supplements.

Consequently, the whole of the medication, together with the consumer products or life habits of the patient, must undergo an evaluation of pharmacological interactions.

Consulting g-Nomic® Pharmacogenetics interpretation software, before prescribing, is an effective aid to avoid most adverse effects or therapeutic failures due to medication.

g-Nomic® interrelates all drugs, herbs, nutritional supplements and lifestyle, with the patient's genes. It also advises the most appropriate dose to prescribe.

This text has been translated automatically using an electronic translator, so the Spanish version should prevail. Please check in case of doubt.

 

Sample type and process to follow

You will receive the sample collection kit. You can request additional kits if you need it.

Sample collection kit content:
You will get a box with sample collection kit. Within the kit you will find:

  1. Saliva collector.
  2. Instructions for the sample collection.
  3. Informed consent sheet and application form.
  4. Security bag to enter the sample for shipment.
  5. Envelope bag.

Process to follow:

  1. Follow the instructions for collecting the sample.
  2. After obtaining the sample, include it in the return envelope, remember to put into the informed consent sheet and the application form.
  3. No shipping costs on Spanish territory.
  4. An email confirmation will be sent when your sample si received.
  5. When the study will be completed you will receive a new e-mail to inform you that your report is already available in "My results".

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