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MERCAPTOPURINEpgx

Pharmacogenetic DNA test for mercaptopurine
Pharmacogenetic DNA test for mercaptopurine
The report includes an interpretation of the results so that it can be used immediately. However, it is necessary to review in a Pharmacogenetic interpretation software g-Nomic, all the medication that the patient takes, as well as their nutritional life habits, to avo...
The report includes an interpretation of the results so that it can be used immediately. However, it is necessary to review in a Pharmacogenetic interpretation software g-Nomic, all the medication that the patient takes, as well as their nutritional life habits, to avoid a therapeutic failure.
369,00

Sample type:

Saliva

Delivery period:

30 - 40 days from sample receipt.
Last update of the document Jun, 10/06/2019 - 13:32

6-mercaptopurina DNA Test 

6-mercaptopurine is a chemotherapeutic agent used for the treatment of acute lymphoblastic leukemia in combination with other medications.

It has been noticed that some individuals have non-functional copies of the TPMT gene and, consequently, have a reduced TPMT activity and a lower ability to eliminate 6-mercaptopurine.

This has been associated with a greater sensitivity to the adverse effects caused by the drug in the form of severe hematopoietic toxicity.

The identification of the deficiencies of TPMT activity due to genetic variation allows to evaluate the prognosis of the treatment with 6-mercaptopurine, anticipating the appearance of hematopoietic toxicity. The genotype of TPMT is a biomarker recognized and validated by the American agency FDA for toxicity due to 6-mercaptopurine.

The other pathway of metabolism of 6-mercaptopurine is the enzyme xanthine oxidase (XO). Some drugs are inhibitors of this enzyme (for example, allopurinol), and if co-administered with 6-mercaptopurine, a toxic effect similar to that which occurs in people with TPMT deficit would be produced.

Process translated by an automatic translator the original version is in Spanish

You will receive the sample collection kit. You can request additional kits if you need it.

Sample collection kit content:
You will get a box with sample collection kit. Within the kit you will find:

  1. Saliva collector.
  2. Instructions for the sample collection.
  3. Informed consent sheet and application form.
  4. Security bag to enter the sample for shipment.
  5. Envelope bag.

Process to follow:

  1. Follow the instructions for collecting the sample.
  2. After obtaining the sample, include it in the return envelope, remember to put into the informed consent sheet and the application form.
  3. No shipping costs on Spanish territory.
  4. An email confirmation will be sent when your sample si received.
  5. When the study will be completed you will receive a new e-mail to inform you that your report is already available in "My results".

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Profile Information

6-mercaptopurina DNA Test 

6-mercaptopurine is a chemotherapeutic agent used for the treatment of acute lymphoblastic leukemia in combination with other medications.

It has been noticed that some individuals have non-functional copies of the TPMT gene and, consequently, have a reduced TPMT activity and a lower ability to eliminate 6-mercaptopurine.

This has been associated with a greater sensitivity to the adverse effects caused by the drug in the form of severe hematopoietic toxicity.

The identification of the deficiencies of TPMT activity due to genetic variation allows to evaluate the prognosis of the treatment with 6-mercaptopurine, anticipating the appearance of hematopoietic toxicity. The genotype of TPMT is a biomarker recognized and validated by the American agency FDA for toxicity due to 6-mercaptopurine.

The other pathway of metabolism of 6-mercaptopurine is the enzyme xanthine oxidase (XO). Some drugs are inhibitors of this enzyme (for example, allopurinol), and if co-administered with 6-mercaptopurine, a toxic effect similar to that which occurs in people with TPMT deficit would be produced.

Process translated by an automatic translator the original version is in Spanish

Sample type and process to follow

You will receive the sample collection kit. You can request additional kits if you need it.

Sample collection kit content:
You will get a box with sample collection kit. Within the kit you will find:

  1. Saliva collector.
  2. Instructions for the sample collection.
  3. Informed consent sheet and application form.
  4. Security bag to enter the sample for shipment.
  5. Envelope bag.

Process to follow:

  1. Follow the instructions for collecting the sample.
  2. After obtaining the sample, include it in the return envelope, remember to put into the informed consent sheet and the application form.
  3. No shipping costs on Spanish territory.
  4. An email confirmation will be sent when your sample si received.
  5. When the study will be completed you will receive a new e-mail to inform you that your report is already available in "My results".

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